B Cell Survival Pathway
| PAG Title | B Cell Survival Pathway |
| PAG ID | WIG000268 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Physical interactions between intergrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, surviving, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,151 |
| Information Content | Rich |
| Other IDs | M4835 |
| Base PAG ID | WIG000268 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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